Lyn [p Tyr396] Antibody (SR2011)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21581

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21581-100ul
NBP3-21581-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2011

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Lyn Antibodies »

Product Summary for Lyn [p Tyr396] Antibody (SR2011)

Immunogen

A synthesized peptide derived from human phospho-Lyn [Tyr396] (Uniprot #: P07948)

Modification

p Tyr 396

Specificity

Detects endogenous levels of total phospho-Lyn [Tyr396]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

56 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Lyn [p Tyr396] Antibody (SR2011)

Western Blot: Lyn [p Tyr 396] Antibody (SR2011) [NBP3-21581] -

Western Blot: Lyn [p Tyr 396] Antibody (SR2011) [NBP3-21581] - Western blot analysis using NBP3-21581 in Jurkat cell lysate treated with Pervanadate.

Applications for Lyn [p Tyr396] Antibody (SR2011)

Application
Recommended Usage

Flow Cytometry

1:50

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Lyn

Src is the human homolog of the v-Src gene of the Rous sarcoma virus, also known as avian sarcoma virus or ASV. Src is the first proto-oncogenic non-receptor tyrosine kinase characterized in human. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility and adhesion. Src-family kinases contain an amino-terminal cell membrane anchor followed by an SH3 domain and an SH2 domain involved in modular association and activation, respectively. Src-family kinases are normally maintained in an inactive state and can be activated transiently during cellular events such as mitosis. The human Lyn gene maps to chromosome 8q13 and encodes a 505 amino acid protein. Hematopoietic tissues predominantly express Lyn, which influences normal immunoglobulin production and regulation.

Long Name

V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog

Alternate Names

Hck-2, JTK8, v-yes-1

Gene Symbol

LYN

Additional Lyn Products

Product Documents for Lyn [p Tyr396] Antibody (SR2011)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Lyn [p Tyr396] Antibody (SR2011)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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