The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM]

Long Name

v-maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog K

Alternate Names

NFE2U

Gene Symbol

MAFK

Additional MafK Products

Product Documents for MafK Antibody (2F7) [Janelia Fluor® 585]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for MafK Antibody (2F7) [Janelia Fluor® 585]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

MafK Antibody (2F7) [Janelia Fluor® 585]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-22570JF585

Key Product Details

Species Reactivity

Validated:

Applications

Label

Antibody Source

Concentration

View all MafK Antibodies »

Product Summary for MafK Antibody (2F7) [Janelia Fluor® 585]

Immunogen

Clonality

Host

Isotype

Applications for MafK Antibody (2F7) [Janelia Fluor® 585]

ELISA

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: MafK