MAP4K1 Antibody (1G6)

Novus Biologicals, part of Bio-Techne | Catalog # H00011184-M02-100ug

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 1G6

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MAP4K1 Antibodies »

Product Specifications

Immunogen

MAP4K1 (NP_009112, 278 a.a. ~ 377 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESS

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for MAP4K1 Antibody (1G6)

Western Blot: MAP4K1 Antibody (1G6) [H00011184-M02-100ug]

Western Blot: MAP4K1 Antibody (1G6) [H00011184-M02-100ug]

Western Blot: MAP4K1 Antibody (1G6) [H00011184-M02-100ug] - Detection against Immunogen (36.63 KDa) .
Western Blot: MAP4K1 Antibody (1G6) [H00011184-M02-100ug]

Western Blot: MAP4K1 Antibody (1G6) [H00011184-M02-100ug]

Western Blot: MAP4K1 Antibody (1G6) [H00011184-M02-100ug] - Monoclonal antibody (M02), clone 1G6. Western Blot analysis of MAP4K1 expression in Jurkat.
ELISA: MAP4K1 Antibody (1G6) [H00011184-M02-100ug]

ELISA: MAP4K1 Antibody (1G6) [H00011184-M02-100ug]

ELISA: MAP4K1 Antibody (1G6) [H00011184-M02-100ug] - Detection limit for recombinant GST tagged MAP4K1 is 0.03 ng/ml as a capture antibody.

Applications for MAP4K1 Antibody (1G6)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: MAP4K1

The hematopoietic progenitor kinase 1 (HPK1) is a mammalian hematopoiesis-specific Ste20 homologue belonging to the germinal center (GC) kinase family, which contains at least 20 kinases (1). HPK1 is implicated in a variety of signaling systems, including epidermal growth factor, transforming growth factor-beta, erythropoietin, prostaglandin E2, and T cell receptor and B cell receptor stimulation. HPK1 is also involved in Fas ligation-mediated apoptosis, NF-B activation and a highly specific activator of the JNK/SAP signaling pathway (2-5). Phosphorylation of HPK1 on threonine 165, serine 171 and tyrosine 379 is a prerequisite for its enzymatic activation in response to immunoreceptor stimulation (6).

Alternate Names

EC 2.7.11, EC 2.7.11.1, Hematopoietic progenitor kinase, HPK1hematopoietic progenitor kinase 1, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, mitogen-activated protein kinase kinase kinase kinase 1

Entrez Gene IDs

11184 (Human)

Gene Symbol

MAP4K1

OMIM

601983 (Human)

UniProt

NP_009112 (Human)

Additional MAP4K1 Products

Product Documents for MAP4K1 Antibody (1G6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for MAP4K1 Antibody (1G6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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