Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation (Negative), Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all MAPKAP Kinase 3 Antibodies »

Product Summary for MAPKAP Kinase 3 Antibody

Immunogen

The immunogen this antibody was made to, maps to a region between residue 1 to 50 of human Chromosome 3p Kinase using the numbering given in entry NP_001230855.1 (GeneID 7867).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MAPKAP Kinase 3 Antibody

Western Blot: MAPKAP Kinase 3 Antibody [NBP2-32092]

Western Blot: MAPKAP Kinase 3 Antibody [NBP2-32092]

Western Blot: MAPKAP Kinase 3 Antibody [NBP2-32092] - Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-MAPKAP Kinase 3 antibody NBP2-32092 used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Immunohistochemistry: MAPKAP Kinase 3 Antibody [NBP2-32092]

Immunohistochemistry: MAPKAP Kinase 3 Antibody [NBP2-32092]

Immunohistochemistry: MAPKAP Kinase 3 Antibody [NBP2-32092] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- 3pK used at a dilution of 1:1,000 (1ug/ml). Detection: DAB. Counterstain: IHC Hematoxylin (blue).

Applications for MAPKAP Kinase 3 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:2000

Immunohistochemistry-Paraffin

1:500 - 1:2000

Western Blot

1:1000 - 1:5000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: MAPKAP Kinase 3

MAPKAP Kinase 3 encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.

Alternate Names

3PKEC 2.7.11.1, Chromosome 3p kinase, EC 2.7.11, MAP kinase-activated protein kinase 3, MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAP33pK, MAPKAPK-3, mitogen-activated protein kinase-activated protein kinase 3

Gene Symbol

MAPKAPK3

UniProt

NP_001230855.1 (Human)

Additional MAPKAP Kinase 3 Products

Product Documents for MAPKAP Kinase 3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MAPKAP Kinase 3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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