Matriptase 2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-57098

Novus Biologicals, part of Bio-Techne
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NBP1-57098
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Matriptase 2 Antibodies »

Product Summary for Matriptase 2 Antibody

Immunogen

Synthetic peptides corresponding to TMPRSS6(transmembrane protease, serine 6) The peptide sequence was selected from the N terminal of TMPRSS6. Peptide sequence LLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for Matriptase 2 Antibody

Western Blot: Matriptase 2 Antibody [NBP1-57098]

Western Blot: Matriptase 2 Antibody [NBP1-57098]

Western Blot: Matriptase 2 Antibody [NBP1-57098] - Titration: 0.2-1 ug/ml, Positive Control: Jurkat cell lysate.
Immunohistochemistry-Paraffin: Matriptase 2 Antibody [NBP1-57098]

Immunohistochemistry-Paraffin: Matriptase 2 Antibody [NBP1-57098]

Immunohistochemistry-Paraffin: Matriptase 2 Antibody [NBP1-57098] - Human Liver tissue, 5 ug/ml.

Applications for Matriptase 2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Matriptase 2

TMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.

Alternate Names

EC 3.4.21, EC 3.4.21.-, FLJ30744, IRIDA, Matriptase-2, membrane-bound mosaic serine proteinase matriptase-2, transmembrane protease serine 6, transmembrane protease, serine 6, type II transmembrane serine protease 6

Gene Symbol

TMPRSS6

UniProt

Q8IU80 (Human)

Additional Matriptase 2 Products

Product Documents for Matriptase 2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Matriptase 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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