MAVS Antibody (58N3B6) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-22380

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 58N3B6

Format

BSA Free

Concentration

1.0 mg/ml

View all MAVS Antibodies »

Product Summary for MAVS Antibody (58N3B6) - BSA Free

Immunogen

Amino acids 93-276 of human MAVS (isoform 1) were used as the immunogen for this antibody.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for MAVS Antibody (58N3B6) - BSA Free

Western Blot: MAVS Antibody (58N3B6)BSA Free [NBP2-22380]

Western Blot: MAVS Antibody (58N3B6)BSA Free [NBP2-22380]

Western Blot: MAVS Antibody (58N3B6) [NBP2-22380] - Analysis of A) partial recombinant protein and B) human HeLa lysate using MAVS antibody at 0.1 ug/ml and 2 ug/ml, respectively. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: MAVS Antibody (58N3B6) - BSA Free [NBP2-22380]

Immunohistochemistry-Paraffin: MAVS Antibody (58N3B6) - BSA Free [NBP2-22380]

Immunohistochemistry-Paraffin: MAVS Antibody (58N3B6) [NBP2-22380] - Normal human spleen tissue stained with MAVS (IPS-1) antibody (3 ug/ml), peroxidase-conjugate and DAB chromogen.

Applications for MAVS Antibody (58N3B6) - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

3-5 ug/ml

Western Blot

2-5 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAVS

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]

Long Name

Mitochondrial Antiviral Signaling Protein

Alternate Names

Cardif, IPS-1, VISA

Gene Symbol

MAVS

UniProt

AAH44952.1 (Human)

Additional MAVS Products

Product Documents for MAVS Antibody (58N3B6) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MAVS Antibody (58N3B6) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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