Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Validated:

Chromatin Immunoprecipitation (ChIP), ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

CoIP

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

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Product Specifications

Immunogen

Antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human VISA. The immunogen is located within the first 50 amino acids of VISA. Amino Acid Squence: CLTARDQDRLRAT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MAVS Antibody - BSA Free

Western Blot: MAVS AntibodyBSA Free [NBP1-77275]

Western Blot: MAVS AntibodyBSA Free [NBP1-77275]

Western Blot: MAVS Antibody [NBP1-77275] - A20 cell lysate with MAVS antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry-Paraffin: MAVS Antibody - BSA Free [NBP1-77275]

Immunohistochemistry-Paraffin: MAVS Antibody - BSA Free [NBP1-77275]

Immunohistochemistry-Paraffin: MAVS Antibody [NBP1-77275] - Human brain tissue with MAVS antibody at 5 ug/ml.

Immunocytochemistry/Immunofluorescence: MAVS Antibody [NBP1-77275] -

Immunocytochemistry/Immunofluorescence: MAVS Antibody [NBP1-77275] - Human Brain cells with VISA antibody at 20 ug/mL.
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Applications for MAVS Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

0.5-2 ug/ml
Application Notes
Use in chromatin immunoprecipitation reported in scientific literature (PMID: 25385820).

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAVS

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

Long Name

Mitochondrial Antiviral Signaling Protein

Alternate Names

Cardif, IPS-1, VISA

Gene Symbol

MAVS

UniProt

NP_065797 (Human)

Additional MAVS Products

Product Documents for MAVS Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MAVS Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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