MAVS Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-49691

Novus Biologicals, part of Bio-Techne
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NBP2-49691
NBP2-49691SS
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all MAVS Antibodies »

Product Specifications

Immunogen

Synthetic peptide made to an internal portion of the human MAVS protein (between amino acids 50-150) [UniProt Q96PD5]

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MAVS Antibody

Western Blot: MAVS Antibody [NBP2-49691]

Western Blot: MAVS Antibody [NBP2-49691]

Western Blot: MAVS Antibody [NBP2-49691] - Whole cell protein from MCF7 and A431 was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2 ug/ml anti-MAVS in 1% milk, and detected with an anti-rabbit HRP secondary antibody using chemiluminescence.

Applications for MAVS Antibody

Application
Recommended Usage

Western Blot

2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAVS

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005).[supplied by OMIM]

Long Name

Mitochondrial Antiviral Signaling Protein

Alternate Names

Cardif, IPS-1, VISA

Gene Symbol

MAVS

UniProt

Q96PD5 (Human)

Additional MAVS Products

Product Documents for MAVS Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for MAVS Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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