MCPH1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89937

Novus Biologicals, part of Bio-Techne
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NBP1-89937
NBP1-89937-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MCPH1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: AVGLKSTQNKGTTSKISNSSEGEAQSEHEPCFIVDCNMETSTEEKENLPGGYSGSVKNRPTRHDVLDDSCDGFKDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGI

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23472065)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MCPH1 Antibody

Western Blot: MCPH1 Antibody [NBP1-89937]

Western Blot: MCPH1 Antibody [NBP1-89937]

Western Blot: MCPH1 Antibody [NBP1-89937] - Analysis in human cell line NTERA-2.
Immunohistochemistry-Paraffin: MCPH1 Antibody [NBP1-89937]

Immunohistochemistry-Paraffin: MCPH1 Antibody [NBP1-89937]

Immunohistochemistry-Paraffin: MCPH1 Antibody [NBP1-89937] - Staining of human testis shows moderate to strong nuclear positivity in cells in seminiferous ducts.
Immunohistochemistry-Paraffin: MCPH1 Antibody [NBP1-89937]

Immunohistochemistry-Paraffin: MCPH1 Antibody [NBP1-89937]

Immunohistochemistry-Paraffin: MCPH1 Antibody [NBP1-89937] - Staining of human cerebellum shows moderate nuclear positivity in Purkinje and granular cell layers.
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Applications for MCPH1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MCPH1

MCPH-1 was identified in a screen for negative regulators of hTERT (human telomerase) expression. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Defects in MCPH1 are the cause of primary microcephaly 1.

Long Name

Microcephalin 1

Alternate Names

BRIT1, MCT, Microcephalin

Gene Symbol

MCPH1

Additional MCPH1 Products

Product Documents for MCPH1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MCPH1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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