MDR1/ABCB1 Antibody (MDR1/8986R)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-23782

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-23782-100ug
NBP3-23782-20ug
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # MDR1/8986R

Concentration

0.2 mg/ml

View all MDR1/ABCB1 Antibodies »

Product Summary for MDR1/ABCB1 Antibody (MDR1/8986R)

Immunogen

Recombinant fragment (around aa500-700) of human MDR1/ABCB1 protein (exact sequence is proprietary)

Localization

Membrane.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Description

Store at 2 to 8C. Non-hazardous. No MSDS required.

Scientific Data Images for MDR1/ABCB1 Antibody (MDR1/8986R)

MDR1/ABCB1 Antibody (MDR1/8986R)

Immunohistochemistry-Paraffin: MDR1/ABCB1 Antibody (MDR1/8986R) [NBP3-23782] -

Formalin-fixed, paraffin-embedded human adrenal gland stained with MDR1/ABCB1 antibody (MDR1/8986R). HIER: Tris/EDTA, pH9.0, 45min. Secondary: HRP-polymer, 30min. DAB, 5min.

Applications for MDR1/ABCB1 Antibody (MDR1/8986R)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml
Application Notes
Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: MDR1/ABCB1

MDR1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. (provided by RefSeq)

Long Name

ATP-binding Cassette, Sub-family B (MDR/TAP), Member 1B

Alternate Names

ABC20, ABCB1, ABCB1B, CD243, CLCS, GP170, IBD13, PGY1

Gene Symbol

ABCB1

Additional MDR1/ABCB1 Products

Product Documents for MDR1/ABCB1 Antibody (MDR1/8986R)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MDR1/ABCB1 Antibody (MDR1/8986R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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