MED6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00010001-D01P

Novus Biologicals, part of Bio-Techne
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H00010001-D01P
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MED6 Antibodies »

Product Specifications

Immunogen

MED6 (NP_005457.2, 1 a.a. - 246 a.a.) full-length human protein. MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ

Specificity

Reacts with mediator complex subunit 6.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MED6 Antibody

Western Blot: MED6 Antibody [H00010001-D01P]

Western Blot: MED6 Antibody [H00010001-D01P]

Western Blot: MED6 Antibody [H00010001-D01P] - Analysis of MED6 expression in mouse liver.
Western Blot: MED6 Antibody [H00010001-D01P]

Western Blot: MED6 Antibody [H00010001-D01P]

Western Blot: MED6 Antibody [H00010001-D01P] - Analysis of MED6 expression in HepG2.
Western Blot: MED6 Antibody [H00010001-D01P]

Western Blot: MED6 Antibody [H00010001-D01P]

Western Blot: MED6 Antibody [H00010001-D01P] - Analysis of MED6 expression in transfected 293T cell line by MED6 polyclonal antibody.Lane 1: MED6 transfected lysate(28.40 KDa).Lane 2: Non-transfected lysate.

Applications for MED6 Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This antibody is reactive against transfected lysate in western blot, and as a detection antibody in ELISA.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: MED6

MED6 also known as Mediator of RNA polymerase II transcription subunit 6, is a 246 amino acid protein that is 28 kDa; as a component of the Mediator complex, a co-activator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, by direct interactions with regulatory proteins the mediator is recruited to promoters and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Disease research is currently being performed with relation to MED6 and spondylolysis, renal carcinoma, carcinoma, renal cell carcinoma, cholesterol, and neuronitis. This protein has also been shown to have interactions with over 70 proteins including SMAD2, SMAD1, CDK8, MED15, and MED25 in developmental biology, transcriptional regulation of white adipocyte differentiation, generic transcription pathway, gene expression, and transcription ligand-dependent transcription of retinoid-target genes pathways.

Alternate Names

Activator-recruited cofactor 33 kDa component, ARC33, mediator complex subunit 6hMed6, mediator of RNA polymerase II transcription subunit 6, mediator of RNA polymerase II transcription, subunit 6 homolog, mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae), NY-REN-28, Renal carcinoma antigen NY-REN-28

Entrez Gene IDs

10001 (Human)

Gene Symbol

MED6

UniProt

NP_005457.2 (Human)

Additional MED6 Products

Product Documents for MED6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MED6 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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