mGluR1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS879

Novus Biologicals, part of Bio-Techne
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NLS879
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Key Product Details

Species Reactivity

Validated:

Human, Bovine, Rabbit

Predicted:

Bat (94%), Canine (94%), Chimpanzee (100%), Equine (94%), Hamster (94%), Monkey (94%), Mouse (94%), Primate (100%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all mGluR1 Antibodies »

Product Specifications

Immunogen

Synthetic 17 amino acid peptide from N-terminal extracellular domain of human mGluR1.

Epitope

N-Terminus extracellular domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (94%), Chicken (88%), Xenopus (82%).

Specificity

Human mGluR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for mGluR1 Antibody - BSA Free

Immunohistochemistry-Paraffin: mGluR1 Antibody - BSA Free [NLS879]

Immunohistochemistry-Paraffin: mGluR1 Antibody - BSA Free [NLS879]

Immunohistochemistry-Paraffin: mGluR1 Antibody [NLS879] - Analysis of anti-GRM1 / MGLUR1 antibody with human brain, neurons and glia.

Applications for mGluR1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

17 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: mGluR1

The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signalregulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. mGluR1 has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. Caution: GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).

Long Name

Metabotropic Glutamate Receptor 1

Alternate Names

GPRC1A, GRM1

Entrez Gene IDs

2911 (Human)

Gene Symbol

GRM1

UniProt

Q13255

Additional mGluR1 Products

Product Documents for mGluR1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for mGluR1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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