MMP-12 Antibody (RM381)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18826

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-18826
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM381

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MMP-12 Antibodies »

Product Summary for MMP-12 Antibody (RM381)

Immunogen

A peptide corresponding to C-terminus of human MMP-12 (Uniprot # P39900)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MMP-12 Antibody (RM381)

MMP-12 Antibody (RM381)

Immunohistochemistry: MMP-12 Antibody (RM381)[NBP3-18826]

Immunohistochemistry: MMP-12 Antibody (RM381)[NBP3-18826]Immunohistochemical staining of formalin fixed and paraffin embedded human lung tissue section using anti-MMP-12 rabbit monoclonal antibody (Clone RM381) at a 1:2500 dilution.
MMP-12 Antibody (RM381)

MMP-12 Antibody (RM381) [NBP3-18826] -

MMP-12 Antibody (RM381) [NBP3-18826] - Western Blot of HEK 293 cells lysate using NBP3-18826 at a 1:500 dilution.

Applications for MMP-12 Antibody (RM381)

Application
Recommended Usage

Immunohistochemistry

1:1000-1:2500

Western Blot

1:200-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: MMP-12

Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested. It is therefore an attractive therapeutic target (1). MMP-12) expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

Long Name

Matrix Metalloproteinase 12

Alternate Names

MMP12

Gene Symbol

MMP12

Additional MMP-12 Products

Product Documents for MMP-12 Antibody (RM381)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MMP-12 Antibody (RM381)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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