MMP-7 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-99123

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Kangaroo

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.28 mg/ml

View all MMP-7 Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to an internal portion of the human MMP7 protein (between residues 250-300) [UniProt P09237]

Localization

Secreted, extracellular space, extracellular matrix

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MMP-7 Antibody - BSA Free

Immunohistochemistry: MMP-7 Antibody - BSA Free [NBP1-99123]

Immunohistochemistry: MMP-7 Antibody - BSA Free [NBP1-99123]

Immunohistochemistry: MMP-7 Antibody [NBP1-99123] - MMP7 antibody was tested in human breast cancer using DAB with hematoxylin counterstain. The image on the right had the antibody blocked by preincubation with immunizing peptide.

Applications for MMP-7 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:300

Immunohistochemistry-Paraffin

1:300
Application Notes
This MMP7 antibody is useful for Immunohistochemistry-paraffin embedded sections, where staining is seen in the extracellular matrix of human breast cancer. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.4)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1.28 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MMP-7

Matrix Metalloproteinases (MMPs) belong to a family of proteases that are essential for the breakdown of extracellular matrix (ECM). They are important in tumor cell growth, invasion, and metastasis, as well as angiogenesis, wound healing, and apoptosis. Most MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin like (Hpx) domain. Matrix metalloproteinase-7 (MMP7), also known as Matrilysin, belongs to the peptidase M10A family, and is responsible for hydrolyzing proteoglycans and ECM glycoproteins. MMP7 will activate procollagenase while degrading gelatin types I, III, IV, and V, and casein. In addition, MMP7 is expressed in normal and cancer cells, specifically glandular epithelial cells and pancreatic carcinoma. Research suggests that MMP7 may play an important role in the early stages of tumor progression.

Long Name

Matrix Metalloproteinase 7

Alternate Names

Matrilysin, MMP7

Entrez Gene IDs

4316 (Human)

Gene Symbol

MMP7

UniProt

P09237

Additional MMP-7 Products

Product Documents for MMP-7 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MMP-7 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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