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MMP-8 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85576

Novus Biologicals, part of Bio-Techne
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NBP1-85576
NBP1-85576-25ul

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MMP-8 Antibody

Immunocytochemistry/ Immunofluorescence: MMP-8 Antibody [NBP1-85576]

Immunocytochemistry/ Immunofluorescence: MMP-8 Antibody [NBP1-85576]

Immunocytochemistry/Immunofluorescence: MMP-8 Antibody [NBP1-85576] - Neurophil MMP-8 associates with NETs. Neutrophils were infected with M.tb MOI of 10 for 4 hours and NETs stained with DAPI (blue), anti-histone 2B (H2B, green) or anti-MMP-8 (green), while M.tb was stained with anti-M.tb Ab (red). Mtb induces NET formation which do not adhere to the shape of the neutrophil nuclei (White arrows). Scale bars represent 25 um. Image collected and cropped by CiteAb from the following publication (dx.plos.org/10.1371/journal.ppat.1004917), licensed under a CC-BY license.
Immunohistochemistry-Paraffin: MMP-8 Antibody [NBP1-85576]

Immunohistochemistry-Paraffin: MMP-8 Antibody [NBP1-85576]

Immunohistochemistry-Paraffin: MMP-8 Antibody [NBP1-85576] - Neutrophil MMP-8 and -9 are upregulated in human TB. Magnified H&E and MMP-8 stains from Fig 1C inset shows neutrophils immunoreactive for MMP-8 around the cavity wall. Scale bar represent 50 um. Image collected and cropped by CiteAb from the following publication (journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004917), licensed under a CC-BY license.
Immunohistochemistry-Paraffin: MMP-8 Antibody [NBP1-85576]

Immunohistochemistry-Paraffin: MMP-8 Antibody [NBP1-85576]

Immunohistochemistry-Paraffin: MMP8 Antibody [NBP1-85576] - Staining of human spleen shows strong cytoplasmic positivity in cells of red pulp.

Applications for MMP-8 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MMP-8

MMP8 is a Metallopeptidase M10A type protease. MMP8 is a Metallopeptidase M10A type protease. It is synthesized and stored intracellularly in specific granules in neutrophils. MMP8 shows a preference for degrading type I collagen.

Long Name

Matrix Metalloproteinase 8

Alternate Names

Collagenase 2, MMP8

Gene Symbol

MMP8

Additional MMP-8 Products

Product Documents for MMP-8 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for MMP-8 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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