MMP21 Antibody (2F10)

Novus Biologicals, part of Bio-Techne | Catalog # H00118856-M01-100ug

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 2F10

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MMP21 Antibodies »

Product Specifications

Immunogen

MMP21 (NP_671724.1, 374 a.a. ~ 481 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. TRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRV

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for MMP21 Antibody (2F10)

Western Blot: MMP21 Antibody (2F10) [H00118856-M01-100ug]

Western Blot: MMP21 Antibody (2F10) [H00118856-M01-100ug]

Western Blot: MMP21 Antibody (2F10) [H00118856-M01-100ug] - Detection against Immunogen (37.62 KDa)
ELISA: MMP21 Antibody (2F10) [H00118856-M01-100ug]

ELISA: MMP21 Antibody (2F10) [H00118856-M01-100ug]

ELISA: MMP21 Antibody (2F10) [H00118856-M01-100ug] - Detection limit for recombinant GST tagged MMP21 is 0.3 ng/ml as a capture antibody.

Applications for MMP21 Antibody (2F10)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: MMP21

Matrix metalloproteinases (MMPs) play key roles in tissue remodelling under normal development and, especially, in diseases ranging from malignancies to stroke. Expression of MMP-21 is controlled uniquely by Pax and Notch transcription factors known to be critical for organogenesis. MMP-21 is expressed transiently in mouse embryogenesis and increased in embryonic neuronal tissues. Observations indicate that there is an important specific function for MMP-21 in embryogenesis, especially in neuronal cells (1). MMP-21 is expressed in various human fetal and adult tissues as well as in cancer cell lines. MMP-21 protein can also be detected in malignancies such as ovarian and colon carcinomas by immunohistochemical staining. Findings suggest that MMP-21 functions in embryogenesis and tumor progression (2). Results suggest that during development, MMP-21 expression is temporally and spatially tightly controlled. Unlike many classical MMPs, it is present in various normal adult tissues. Among epithelial MMPs, MMP-21 has a unique expression pattern in cancer (3).

Long Name

Matrix metalloproteinase-21

Alternate Names

MMP-21

Entrez Gene IDs

118856 (Human)

Gene Symbol

MMP21

OMIM

608416 (Human)

UniProt

NP_671724.1 (Human)

Additional MMP21 Products

Product Documents for MMP21 Antibody (2F10)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for MMP21 Antibody (2F10)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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