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Mouse IGSF8/CD316 Biotinylated Antibody

R&D Systems, part of Bio-Techne | Catalog # BAF3117

R&D Systems, part of Bio-Techne
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BAF3117

Key Product Details

Species Reactivity

Mouse

Applications

Flow Cytometry, Immunocytochemistry, Western Blot

Label

Biotin

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse IGSF8/CD316
Ala25-Thr577
Accession # NP_536344

Specificity

Detects mouse IGSF8/CD316 in Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human IGSF8 is observed and less than 1% cross-reactivity with recombinant mouse IGSF4 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Mouse IGSF8/CD316 Biotinylated Antibody

IGSF8/CD316 antibody in Neuro-2A Mouse Cell Line by Immunocytochemistry (ICC).

IGSF8/CD316 in Neuro‑2A Mouse Cell Line.

IGSF8/CD316 was detected in immersion fixed Neuro-2A mouse neuroblastoma cell line using Goat Anti-Mouse IGSF8/CD316 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF3117) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Streptavidin (red; Catalog # NL999) and counterstained with DAPI (blue). Specific staining was localized to cell surfaces. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Applications for Mouse IGSF8/CD316 Biotinylated Antibody

Application
Recommended Usage

Flow Cytometry

0.25 µg/106 cells
Sample: Neuro-2A mouse neuroblastoma cell line

Immunocytochemistry

5-15 µg/mL
Sample: Immersion fixed Neuro2A mouse neuroblastoma cell line

Western Blot

0.1 µg/mL
Sample: Recombinant Mouse IGSF8

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IGSF8/CD316

IGSF8, also known as PGRL (PG regulatory-like protein), KASP (KAI/CD82 associated protein) and EWI-2 (Glu-Trp-Ile motif 2), is a widely expressed transmembrane adhesion protein. It interacts with beta1 Integrins and various tetraspanins including CD9, CD81 and CD82. IGSF8 contains four extracellular Ig-like domains. IGSF8 overexpression in transformed cells inhibits cell migration and suppresses cancer metastatic potential. Mouse and human IGSF8 share 90% amino acid sequence identity.

Long Name

Immunoglobulin Superfamily, Member 8

Alternate Names

CD316, CD81P3, EWI2, KCT4, PGRL

Entrez Gene IDs

93185 (Human); 140559 (Mouse)

Gene Symbol

IGSF8

UniProt

Additional IGSF8/CD316 Products

Product Documents for Mouse IGSF8/CD316 Biotinylated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Mouse IGSF8/CD316 Biotinylated Antibody

For research use only

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