Mrc2 Antibody (SR1302)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22115

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22115-100ul
NBP3-22115-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1302

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Mrc2 Antibodies »

Product Summary for Mrc2 Antibody (SR1302)

Immunogen

A synthesized peptide derived from human Mrc2 (Uniprot #: Q9UBG0)

Specificity

Detects endogenous levels of total Mrc2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

190 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Mrc2 Antibody (SR1302)

Western Blot: Mrc2 Antibody (SR1302) [NBP3-22115] -

Western Blot: Mrc2 Antibody (SR1302) [NBP3-22115] - Western blot analysis using NBP3-22115 in Saos2 cell lysate.

Applications for Mrc2 Antibody (SR1302)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Mrc2

MRC2, also known as C-type mannose receptor 2, is a 1,479 amino acid protein that is 167 kDa, plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands, may be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface, and may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. Disease research is currently being studied with relations to MRC2 and breast cancer, aortic aneurysm, prostate cancer, progression of osteoarthritis, prostatitis,s, schizophrenia, tuberculosis, immunodeficiency, and hepatitis. Interactions with this protein have shown to involve NDEL1, IL10, TGFB1, TGFB2, TGFB3, and UBC in antigen processing-cross presentation, cross-presentation of soluble exogenous antigens (endosomes), adaptive immune system, class I MHC mediated antigen processing & presentation, immune system, phagosome, and tuberculosis pathways.

Long Name

Mannose Receptor, C-type 2

Alternate Names

CD280, CLEC13E, Endo180, uPARAP

Gene Symbol

MRC2

Additional Mrc2 Products

Product Documents for Mrc2 Antibody (SR1302)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Mrc2 Antibody (SR1302)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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