MRGX2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB110-75035

Novus Biologicals, part of Bio-Techne
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NB110-75035
NB110-75035-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Hamster (Negative)

Cited:

Human, Mouse

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Knockdown Validated, Single Cell Western, Western Blot

Cited:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Knockdown Validated, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all MRGX2 Antibodies »

Product Specifications

Immunogen

A synthetic peptide from the 4th cytoplasmic loop of human MRGX2 conjugated to blue carrier protein was used as the antigen.

Reactivity Notes

Mouse reactivity reported in (PMID: 34008339).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for MRGX2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200-1:2000

Western Blot

1:200-1:2000
Application Notes
Use in ICC/IF reported in scientfic publication (PMID: 32391014). Flow, WB, KD reactivity reported in scientific thesis.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Unpurified

Reconstitution

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the sample size is provided in reconstituted format.

Formulation

Lyophilized from whole antisera

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MRGX2

FUNCTION: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.

Long Name

Mas-related G Protein-coupled Receptor Member X2

Alternate Names

MRGPRX2

Entrez Gene IDs

117194 (Human)

Gene Symbol

MRGPRX2

UniProt

Q96LB1

Additional MRGX2 Products

Product Documents for MRGX2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for MRGX2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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