MSPR/Ron Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-02377

Novus Biologicals, part of Bio-Techne
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NBP1-02377
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Key Product Details

Species Reactivity

Validated:

Human, Bat, Monkey

Predicted:

Canine (94%), Primate (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all MSPR/Ron Antibodies »

Product Specifications

Immunogen

Synthetic 18 amino acid peptide from internal region of human MSPR/Ron.

Epitope

Internal region

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Panda (100%), Gibbon (94%), Hamster (89%), Elephant (89%), Marmoset (83%), Equine (83%).

Specificity

Human MSPR/Ron. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for MSPR/Ron Antibody - BSA Free

Immunohistochemistry-Paraffin: MSPR/Ron Antibody - BSA Free [NBP1-02377]

Immunohistochemistry-Paraffin: MSPR/Ron Antibody - BSA Free [NBP1-02377]

Immunohistochemistry-Paraffin: MSPR/Ron Antibody - BSA Free [NBP1-02377] - Staining of human colon, surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.

Applications for MSPR/Ron Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

2-4 ug/ml

Immunohistochemistry-Paraffin

5-10 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: MSPR/Ron

MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers.

Long Name

Macrophage Stimulating Protein Receptor

Alternate Names

CD136, MSP R, MST1R, Ron

Entrez Gene IDs

4486 (Human)

Gene Symbol

MST1R

UniProt

Q04912

Additional MSPR/Ron Products

Product Documents for MSPR/Ron Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MSPR/Ron Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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