MST2/STK3 Antibody (3C3)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26298

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 3C3

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all MST2/STK3 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from Human MST2/STK3 [UniProt Q13188]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MST2/STK3 Antibody (3C3)

MST2/STK3 Antibody (3C3)

Western Blot: MST2/STK3 Antibody (3C3) [NBP3-26298] -

Western Blot: MST2/STK3 Antibody (3C3) [NBP3-26298] - Positive Western Blot detected in: U251 whole cell lysate, U87 whole cell lysate, MCF-7 whole cell lysate, Hela whole cell lysate.
All lanes: MST2/STK3 Antibody at 1: 2000
Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution.
Predicted band size: 57, 60 kDa
Observed band size: 50-70 kDa

Applications for MST2/STK3 Antibody (3C3)

Application
Recommended Usage

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl and 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: MST2/STK3

Mammalian Sterile 20-Like 2 (Mst2) is most similar to the previously identified Mst1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in-vitro kinase assay indicates that Mst2 can phosphorylate an exogenous substrate, as well as itself, and phospho-amino-acid analysis indicates that it is a serine/threonine protein kinase (1) Mst2, a STE20-family member and purported Hpo ortholog, phosphorylates and activates both Lats1 and Lats2. Results indicate that Mst2-like kinases regulate Lats kinase activities in an evolutionarily conserved regulatory pathway (2). When stably expressed in HeLa cells, Mst highly sensitizes the cells to death receptor-mediated apoptosis by accelerating caspase-3 activation. These findings suggest that Mst1 and Mst2 play a role in apoptosis both upstream and downstream of caspase activation (3).

Alternate Names

KRS1, Mess1, MST3, STK3

Gene Symbol

STK3

Additional MST2/STK3 Products

Product Documents for MST2/STK3 Antibody (3C3)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MST2/STK3 Antibody (3C3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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