Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 2C1E11

Format

BSA Free

Concentration

1.1 mg/ml

View all MTBP Antibodies »

Product Specifications

Immunogen

Recombinant full-length human MTBP

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Clone also known as 14 or T14.

Scientific Data Images for MTBP Antibody (2C1E11) - BSA Free

Western Blot: MTBP Antibody (2C1E11)BSA Free [NBP2-50517]

Western Blot: MTBP Antibody (2C1E11)BSA Free [NBP2-50517]

Western Blot: MTBP Antibody (2C1E11) [NBP2-50517] - Western blot analysis using H1299 and MCF7 lysates. 7.5% gel, 25 ug/well.
Western Blot: MTBP Antibody (2C1E11)BSA Free [NBP2-50517]

Western Blot: MTBP Antibody (2C1E11)BSA Free [NBP2-50517]

Western Blot: MTBP Antibody (2C1E11) [NBP2-50517] - Western blot analysis comparing binding to murine and human MTBP

Applications for MTBP Antibody (2C1E11) - BSA Free

Application
Recommended Usage

Western Blot

3 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MTBP

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

Alternate Names

hMTBP, MDM2 (mouse double minute 2)-binding protein, 104kD, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) bindingprotein, 104kDa, mdm2-binding protein, MDM2BP

Gene Symbol

MTBP

Additional MTBP Products

Product Documents for MTBP Antibody (2C1E11) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for MTBP Antibody (2C1E11) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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