mtTFA Antibody (18G102B2E11) [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-71648V

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP1-71648

Alexa Fluor 350

NBP1-71648AF350

Alexa Fluor 405

NBP1-71648AF405

Alexa Fluor 488

NBP1-71648AF488

Alexa Fluor 532

NBP1-71648AF532

Alexa Fluor 594

NBP1-71648AF594

Alexa Fluor 647

NBP1-71648AF647

Alexa Fluor 700

NBP1-71648AF700

Alexa Fluor 750

NBP1-71648AF750

Biotin

NBP1-71648B

CoraFluor 1

NBP1-71648CL1

DyLight 350

NBP1-71648UV

DyLight 488

NBP1-71648G

DyLight 550

NBP1-71648R

DyLight 594

NBP1-71648DL594

DyLight 650

NBP1-71648C

DyLight 680

NBP1-71648FR

DyLight 755

NBP1-71648IR

FITC

NBP1-71648F

HRP

NBP1-71648H

Janelia Fluor 525

NBP1-71648JF525

Janelia Fluor 549

NBP1-71648JF549

Janelia Fluor 585

NBP1-71648JF585

Janelia Fluor 635

NBP1-71648JF635

Janelia Fluor 646

NBP1-71648JF646

Janelia Fluor 669

NBP1-71648JF669

mFluor Violet 450 SE

NBP1-71648MFV450

mFluor Violet 500 SE

NBP1-71648MFV500

mFluor Violet 610 SE

NBP1-71648MFV610

Forumulation

Catalog #

Azide and BSA Free

NBP2-80858

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockdown Validated, Knockout Validated, Simple Western, Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 18G102B2E11

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all mtTFA Antibodies »

Product Specifications

Immunogen

Human mtTFA [Swiss-Prot# Q00059]

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 28053692)

Localization

Mitochondrion.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Applications for mtTFA Antibody (18G102B2E11) [DyLight 405]

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Knockout Validated

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: mtTFA

mtTFA (transcription factor A, mitochondrial) is an essential protein that binds mitochondrial DNA (mtDNA) with or without sequence specificity to control mitochondrial transcription initiation and mtDNA copy number. mtTFA exists as monomer localized in mitochondrion matrix / nucleoid where it binds DNA and interacts with TFB1M/TFB2M. mtTFA associate with mitochondrial light strand promoter for controlling transcription and is essential for correct/efficient mtRNA polymerase promoter recognition. mtTFA is capable of unwinding DNA and bending mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes, and mtTFA is essential for controlling mtDNA levels as well as its organization/compaction. mtDNA is a multicopy, circular genome that is unquestionably required for respiratory function and interference with mitochondrial genome sequence fidelity, transcription, or translation can cause ATP insufficiency and several pathologies including progressive external ophthalmoplegia, amyotrophic lateral sclerosis (ALS), Alpers' disease, Parkinson's disease, Alzheimer's disease, aging, cardiovascular disease, diabetes and cancer.

Alternate Names

mitochondrial transcription factor A, MTTF1, mtTFA, TCF-6, TCF6L1, TCF6L2Mitochondrial transcription factor 1, TCF6TCF6L3, Transcription factor 6, Transcription factor 6-like 2, Transcription factor 6-like 2 (mitochondrial transcription factor), transcription factor A, mitochondrial

Gene Symbol

TFAM

Additional mtTFA Products

Product Documents for mtTFA Antibody (18G102B2E11) [DyLight 405]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for mtTFA Antibody (18G102B2E11) [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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