Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Musashi-2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human MSI2. The immunogen is located within amino acids 30 - 80 of MSI2. Amino Acid Squence: MVMRDPTTKRSRGF

Specificity

MSI2 antibody is predicted to not cross-react with MSI1. Multiple isoforms of MSI2 are known to exist.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Musashi-2 Antibody - BSA Free

Western Blot: Musashi-2 AntibodyBSA Free [NBP1-76575]

Western Blot: Musashi-2 AntibodyBSA Free [NBP1-76575]

Western Blot: Musashi-2 Antibody [NBP1-76575] - Analysis of MSI2 in EL4 cell lysate with MSI2 antibody at 1 ug/mL.

Immunocytochemistry/Immunofluorescence: Musashi-2 Antibody [NBP1-76575] -

Immunocytochemistry/Immunofluorescence: Musashi-2 Antibody [NBP1-76575] - EL4 cells with MSI2 antibody at 5 ug/mL.
Immunohistochemistry-Paraffin: Musashi-2 Antibody - BSA Free [NBP1-76575]

Immunohistochemistry-Paraffin: Musashi-2 Antibody - BSA Free [NBP1-76575]

Immunohistochemistry-Paraffin: Musashi-2 Antibody [NBP1-76575] - Staining of MSI2 in mouse brain tissue with MSI2 Antibodyat 5 ug/mL.
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Applications for Musashi-2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

5 ug/mL

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Musashi-2

Musashi2 (MSI2) is an RNA-binding protein that is highly expressed in precursor cells in the ventricular and subventricular zones of the developing mammalian CNS. Like the related MSI1, MSI2 has been suggested to be involved stem cell production and maintenance. MSI2 is the predominant MSI protein in hematopoietic stem cells, and its knockdown leads to reduced engraftment and depletion in vivo. Expression levels of MSI2 are elevated in myeloid leukemia cells lines, and MSI2 appears to cooperate with BCR-ABL1 to induce an aggressive leukemia; the level of MSI2 directly correlates with decreased survival in patients. MSI2 negatively regulates the asymmetric cell fate determinant NUMB, suggesting that this signaling pathway may provide future targets for future therapies.

Alternate Names

MSI2, Musashi2

Gene Symbol

MSI2

UniProt

EAW94506 (Human)

Additional Musashi-2 Products

Product Documents for Musashi-2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Musashi-2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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