MyBPC3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-13631

Novus Biologicals, part of Bio-Techne
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NBP2-13631
NBP2-13631-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Single Cell Western

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MyBPC3 Antibodies »

Product Summary for MyBPC3 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: QPAFTGSYRCEVSTKDKFDCSNFNLTVHEAMGTGDLDLLSAFRRTSLAGGGRRISDSHEDTGILDFSSLLKKRDSFRTPRDSKLEAPAEEDVWEILRQ

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%), Rat (82%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MyBPC3 Antibody

Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631]

Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631]

Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631] - Analysis in human heart muscle and prostate tissues. Corresponding MyBPC3 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631]

Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631]

Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631] - Staining of human endometrium, heart muscle, pancreas and prostate using Anti-MyBPC3 antibody NBP2-13631 (A) shows similar protein distribution across tissues to independent antibody NBP2-13632 (B).
Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631]

Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631]

Immunohistochemistry-Paraffin: MyBPC3 Antibody [NBP2-13631] - Staining of human prostate shows no positivity in smooth muscle cells or glandular cells as expected.
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Applications for MyBPC3 Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Single Cell Western

Single Cell Western reported by an internal validation on iPSC-derived cardiomyocytes at a 1:10 dilution
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MyBPC3

Cardiac myosin binding protein C3 (MyBPC3) is a 140 kDa thick filament-associated protein located in the crossbridge region of cardiac muscle sarcomeres. It is composed of eight Ig-like domains and three fibronectin 3-like domains and is known to be a physiological substrate of cAMP-dependent protein kinase. MyBPC3 has a role in sarcomeric structure and in the regulation of cardiac muscle contraction. MyBPC3 is released into the coronary effluent during myocardial infarction. Mutations in MyBPC3 are associated with hypertrophic cardiomyopathy.

Long Name

Myosin Binding Protein C, Cardiac

Alternate Names

C-protein, cardiac muscle isoform, CMH4, FHC, MYBP-C

Gene Symbol

MYBPC3

Additional MyBPC3 Products

Product Documents for MyBPC3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for MyBPC3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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