Myelin PLP Antibody (CL10622)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-07989

Novus Biologicals, part of Bio-Techne
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NBP3-07989-100ul
NBP3-07989-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human, Rat

Predicted:

Mouse (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL10622

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Myelin PLP Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: LLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGI

Epitope

GQKGRGSRGQHQAHS

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Myelin PLP Antibody (CL10622)

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989]

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989]

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Analysis in human cerebral cortex and tonsil tissues using NBP3-07989 antibody. Corresponding Myelin PLP RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989]

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989]

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Staining of human tonsil shows no positivity in lymphoid cells as expected.
Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989]

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989]

Immunohistochemistry-Paraffin: Myelin PLP Antibody (CL10622) [NBP3-07989] - Staining of human cerebellum shows strong positivity in myelinated neuronal processes.
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Applications for Myelin PLP Antibody (CL10622)

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, containing 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Myelin PLP

Human PLP (also known as lipophilin) is a 30 kDa protein (277 amino acids) found in myelin of the CNS and PNS. Expressed by oligodendrocytes and Schwann cells, PLP stabilizes myelin by preventing lipid bilayer fusion, and aids in compaction. Different mutations of the human PLP gene product result in two neurological disorders - Pelizaeus-Merzbacher disease and Spastic Paraplegia type 2.

Long Name

Proteolipid Protein

Alternate Names

DM-20, Lipophilin, MMPL, PLP1, SPG2

Gene Symbol

PLP1

Additional Myelin PLP Products

Product Documents for Myelin PLP Antibody (CL10622)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Myelin PLP Antibody (CL10622)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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