Myeloperoxidase/MPO Antibody (RM407)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-89098

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM407

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Myeloperoxidase/MPO Antibodies »

Product Summary for Myeloperoxidase/MPO Antibody (RM407)

Immunogen

A peptide corresponding to the internal region of light chain on Myeloperoxidase/MPO.

Reactivity Notes

This antibody may also react to mouse or rat Myeloperoxidase/MPO, as predicted by immunogen homology.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Myeloperoxidase/MPO Antibody (RM407)

Western Blot: Myeloperoxidase/MPO Antibody (RM407) [NBP2-89098]

Western Blot: Myeloperoxidase/MPO Antibody (RM407) [NBP2-89098]

Western Blot: Myeloperoxidase/MPO Antibody (RM407) [NBP2-89098] - Western Blot of HL60 cell lysate using Anti-MPO rabbit monoclonal antibody (Clone RM407) at a 1:200 dilution.
Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody (RM407) [NBP2-89098]

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody (RM407) [NBP2-89098]

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody (RM407) [NBP2-89098] - Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using Anti-MPO Rabbit Monoclonal Antibody (Clone RM407) at a 1:100 dilution.
Myeloperoxidase/MPO Antibody (RM407)

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody (RM407) [NBP2-89098] -

Immunohistochemistry-Paraffin: Myeloperoxidase/MPO Antibody (RM407) [NBP2-89098] - Immunohistochemical staining of formalin fixed and paraffin embedded human cholangiocarcinoma tissue section using NBP2-89098 at 1:100 dilution.

Applications for Myeloperoxidase/MPO Antibody (RM407)

Application
Recommended Usage

Immunohistochemistry

1:100 - 1:200

Immunohistochemistry-Paraffin

1:100 - 1:200

Western Blot

1:200 - 1:500
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Myeloperoxidase/MPO

FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. MPO is an important marker for myeloid cells, from the promyelocyte stage and to the mature forms. CATALYTIC ACTIVITY: Donor + H2O2 = oxidized donor + 2 H2O. CATALYTIC ACTIVITY: Cl- + H2O2 = HOCl + 2 H2O. COFACTOR: Binds 1 calcium ion per heterodimer. COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer. SUBUNIT: Tetramer of two light chains and two heavy chains. SUBCELLULAR LOCATION: Lysosome. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD). MPD is an autosomal recessive defect that results in disseminated candidiasis. SIMILARITY: Belongs to the peroxidase family. XPO subfamily.

Alternate Names

MPO

Gene Symbol

MPO

Additional Myeloperoxidase/MPO Products

Product Documents for Myeloperoxidase/MPO Antibody (RM407)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Myeloperoxidase/MPO Antibody (RM407)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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