NEU-1/Sialidase-1 Antibody (OTI3H4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-44879

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI3H4

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all NEU-1/Sialidase-1 Antibodies »

Product Specifications

Immunogen

Human recombinant protein fragment corresponding to amino acids 48-315 of human NEU1 (NP_000425)produced in E.coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for NEU-1/Sialidase-1 Antibody (OTI3H4)

Application
Recommended Usage

Western Blot

1:2000

Formulation, Preparation, and Storage

Purification

>95%

Formulation

PBS (pH 7.3) 1% BSA, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 degrees C. Avoid freeze/thaw cycles.

Background: NEU-1/Sialidase-1

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon heterodimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.

Long Name

N-acetyl-alpha-Neuraminidase 1

Alternate Names

NEU1, Sialidase-1

Gene Symbol

NEU-1/Sialidase-1

Additional NEU-1/Sialidase-1 Products

Product Documents for NEU-1/Sialidase-1 Antibody (OTI3H4)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for NEU-1/Sialidase-1 Antibody (OTI3H4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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