Neuropilin-1 Antibody (vesencumab)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28569

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # vesencumab

Concentration

LYOPH mg/ml

View all Neuropilin-1 Antibodies »

Product Specifications

Immunogen

NRP1 / VEGF165R / CD304

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'vesencumab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for Neuropilin-1 Antibody (vesencumab)

Neuropilin-1 Antibody (vesencumab)

ELISA: Neuropilin-1 Antibody (vesencumab)[NBP3-28569] -

Immobilized human NRP1 His at 2 ug/mL can bind Neuropilin-1 Antibody (vesencumab), EC50=0.005571 ug/mL.
Neuropilin-1 Antibody (vesencumab)

Flow Cytometry: Neuropilin-1 Antibody (vesencumab)[NBP3-28569] -

Human NRP1 HEK293 cells were stained with Neuropilin-1 Antibody (vesencumab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.1948 ug/mL.

Applications for Neuropilin-1 Antibody (vesencumab)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Neuropilin-1

Neuropilin-1/CD304 is a type-I transmembrane protein. It forms a heterodimeric complex with vascular endothelial growth factor receptor 2, and this complex functions as a receptor for vascular endothelial growth factor. On the other hand, Neuropilin-1/CD304 forms a complex with plexin-1, and this complex acts as a semaphorin 3A receptor. Neuropilin-1/CD304 is involved in angiogenesis, axon guidance, cell survival, migration, and invasion. Recently, it has been reported that Neuropilin-1/CD304 is an essential component located on the immunological synapse and acts as a potent cell-surface marker for murine regulatory T cells (Treg). Neuropilin-1/CD304 expressed by Treg cells promotes long interactions between Treg cells and immature dendritic cells and restricts access of effector cells to the antigen-presenting cells.

Alternate Names

BDCA-4, CD304, Neuropilin1, NRP1

Gene Symbol

NRP1

UniProt

O14786 (Human)

Additional Neuropilin-1 Products

Product Documents for Neuropilin-1 Antibody (vesencumab)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Neuropilin-1 Antibody (vesencumab)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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