Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61739

Novus Biologicals, part of Bio-Techne
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NBP2-61739
NBP2-61739-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Mouse

Applications

Validated:

ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 7F10G1

Format

BSA Free

Concentration

1 mg/ml

View all Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibodies »

Product Specifications

Immunogen

Purified recombinant fragment of human Nicotinic Acetylcholine R alpha 7/CHRNA7 (AA: extra 52-259) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

56.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free

Western Blot: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1)BSA Free [NBP2-61739]

Western Blot: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1)BSA Free [NBP2-61739]

Western Blot: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) [NBP2-61739] - Analysis using CHRNA7 mAb against human CHRNA7 (AA: extra 52-259) recombinant protein. (Expected MW is 50.4 kDa)
Immunohistochemistry-Paraffin: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free [NBP2-61739]

Immunohistochemistry-Paraffin: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free [NBP2-61739]

Immunohistochemistry-Paraffin: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) [NBP2-61739] - Analysis of rectum cancer tissues using CHRNA7 mouse mAb with DAB staining.
Flow Cytometry: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free [NBP2-61739]

Flow Cytometry: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free [NBP2-61739]

Flow Cytometry: Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) [NBP2-61739] - Analysis of SH-SY5Y cells using CHRNA7 mouse mAb (green) and negative control (red).
View 3 more images

Applications for Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Flow Cytometry

1:10-1:1000

Immunohistochemistry

1:10-1:1000

Immunohistochemistry-Paraffin

1:200 - 1:1000

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Nicotinic Acetylcholine R alpha 7/CHRNA7

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Long Name

Nicotinic Acetylcholine Receptor alpha 7

Alternate Names

CHRNA7, CHRNA7-2, Nicotinic Acetylcholine Ra 7

Gene Symbol

CHRNA7

Additional Nicotinic Acetylcholine R alpha 7/CHRNA7 Products

Product Documents for Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Nicotinic Acetylcholine R alpha 7/CHRNA7 Antibody (7F10G1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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