Niemann-Pick C1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-26214

Novus Biologicals, part of Bio-Techne
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NBP2-26214
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Niemann-Pick Type C1/NPC1 Antibodies »

Product Summary for Niemann-Pick C1 Antibody

Immunogen

Peptide with sequence C-TYHTVLQTSADFID corresponding to internal region according to NP_000262.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Niemann-Pick C1 Antibody

Western Blot: Niemann-Pick C1 Antibody [NBP2-26214]

Western Blot: Niemann-Pick C1 Antibody [NBP2-26214]

Western Blot: Niemann-Pick C1 Antibody [NBP2-26214] - Staining of HEK293 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Niemann-Pick C1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:128000

Western Blot

0.5 - 1.5 ug/ml
Application Notes
WB: Approx. 170 kDa band observed in HEK293 lysates (calculated MW of 142 kDa band according to NP_000262.2).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Niemann-Pick Type C1/NPC1

Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins containing putative sterol sensing domains. The protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. NPC1 overexpression increases both the rate of trafficking of low density lipoprotein cholesterol to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma membrane. NPC disease is an inherited neurovisceral lipid storage disorder of unesterified cholesterol accumulation in lysosomes. It is characterized by progressive neural and liver degeneration, resulting from inactivating mutations in NPC1, in most cases.

Alternate Names

NPC1, SLC65A1

Entrez Gene IDs

4864 (Human)

Gene Symbol

NPC1

Additional Niemann-Pick Type C1/NPC1 Products

Product Documents for Niemann-Pick C1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Niemann-Pick C1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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