Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all NLRP1/NALP1 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human NALP1. The immunogen is located within the last 50 amino acids of NALP1. Amino Acid Squence: EKGSKKGLLPLSS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NLRP1/NALP1 Antibody - BSA Free

Western Blot: NLRP1/NALP1 AntibodyBSA Free [NBP1-76656]

Western Blot: NLRP1/NALP1 AntibodyBSA Free [NBP1-76656]

Western Blot: NLRP1/NALP1 Antibody [NBP1-76656] - U937 cell lysate with NALP1 antibody at (A) 1, (B) 2 and (C) 4 ug/ml.
NLRP1/NALP1 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: NLRP1/NALP1 Antibody - BSA Free [NBP1-76656] -

Immunocytochemistry/ Immunofluorescence: NLRP1/NALP1 Antibody - BSA Free [NBP1-76656] - Immunofluorescence of NLRP1/NALP1 in K562 cells with NLRP1/NALP1 antibody at 20 ug/mL.
NLRP1/NALP1 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: NLRP1/NALP1 Antibody - BSA Free [NBP1-76656] -

Immunocytochemistry/ Immunofluorescence: NLRP1/NALP1 Antibody - BSA Free [NBP1-76656] - Immunocytochemistry of NLRP1/NALP1 in K562 cells with NLRP1/NALP1 antibody at 10 ug/mL.

Applications for NLRP1/NALP1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10-20 ug/mL

Western Blot

1-4 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NLRP1/NALP1

NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1. Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis. NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1.

Long Name

NLR Family, Pyrin Domain Containing 1

Alternate Names

CARD7, CLR17.1, DEFCAP, NALP1, PP1044, SLEV1, VAMAS1

Gene Symbol

NLRP1

UniProt

AAG30288 (Human)

Additional NLRP1/NALP1 Products

Product Documents for NLRP1/NALP1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NLRP1/NALP1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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