Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all NLRP7 Antibodies »

Product Specifications

Immunogen

Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7. The immunogen is located within amino acids 90 - 140 of NALP7. Amino Acid Squence: LGDAEEDSELAKPGEKEG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NLRP7 Antibody - BSA Free

NLRP7 Antibody - BSA Free

Immunohistochemistry: NLRP7 Antibody - BSA Free [NBP1-76290] -

Immunohistochemistry: NLRP7 Antibody - BSA Free [NBP1-76290] - Immunohistochemistry of NLRP7 in human brain tissue with NLRP7 antibody at 10 u/mL.
NLRP7 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: NLRP7 Antibody - BSA Free [NBP1-76290] -

Immunocytochemistry/ Immunofluorescence: NLRP7 Antibody - BSA Free [NBP1-76290] - Immunofluorescence of NLRP7 in human brain tissue with NLRP7 antibody at 20 u/mL.
Western Blot: NLRP7 AntibodyBSA Free [NBP1-76290]

Western Blot: NLRP7 AntibodyBSA Free [NBP1-76290]

Western Blot: NLRP7 Antibody [NBP1-76290] - Analysis of NALP7 in K562 cell lysate with NALP7 antibody at 2 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Applications for NLRP7 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

10 ug/ml

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NLRP7

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

Long Name

NLR Family Pyrin Domain Containing 7

Alternate Names

CLR19.4, NALP7, NOD12, PAN7, PYPAF3

Gene Symbol

NLRP7

UniProt

NP_631915 (Human)

Additional NLRP7 Products

Product Documents for NLRP7 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NLRP7 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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