NMDAR1 Antibody (JM11-26)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-66982

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # JM11-26

Concentration

1 mg/ml

View all NMDAR1 Antibodies »

Product Specifications

Immunogen

Synthetic peptide within human NMDAR1 aa 870-910. (SwissProt: Q05586 Human; SwissProt: P35438 Mouse; SwissProt: P35439 Rat)

Localization

Cell membrane, postsynaptic cell membrane, postsynaptic density.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NMDAR1 Antibody (JM11-26)

Western Blot: NMDAR1 Antibody (JM11-26) [NBP2-66982]

Western Blot: NMDAR1 Antibody (JM11-26) [NBP2-66982]

Western Blot: NMDAR1 Antibody (JM11-26) [NBP2-66982] - Analysis of NMDAR1 on different cells lysates using anti-NMDAR1 antibody at 1/500 dilution. Positive control: Line 1: MCF-7 Line 2: A549
Immunocytochemistry/ Immunofluorescence: NMDAR1 Antibody (JM11-26) [NBP2-66982]

Immunocytochemistry/ Immunofluorescence: NMDAR1 Antibody (JM11-26) [NBP2-66982]

Immunocytochemistry/Immunofluorescence: NMDAR1 Antibody (JM11-26) [NBP2-66982] - Staining NMDAR1 in SH-SY5Y cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Immunohistochemistry-Paraffin: NMDAR1 Antibody (JM11-26) [NBP2-66982]

Immunohistochemistry-Paraffin: NMDAR1 Antibody (JM11-26) [NBP2-66982]

Immunohistochemistry-Paraffin: NMDAR1 Antibody (JM11-26) [NBP2-66982] - Analysis of paraffin-embedded rat brain tissue using anti-NMDAR1 antibody. Counter stained with hematoxylin.
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Applications for NMDAR1 Antibody (JM11-26)

Application
Recommended Usage

Flow Cytometry

1:50-1:100

Immunocytochemistry/ Immunofluorescence

1:100-1:500

Immunohistochemistry-Paraffin

1:50-1:800

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

TBS (pH7.4), 0.05% BSA, 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NMDAR1

N-methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that have a high permeability to calcium found in the central nervous system. The receptor consists of a number of distinct ligand binding domains, and the presence of both glutamate and glycine are required for full activation of the channel. Within the channel there is also a binding site for magnesium, which, when occupied, propagates a voltage-dependent channel block. Other binding sites are also found in the receptor, including a zinc-binding site and an inter-channel site that binds specific channel blockers such as phencyclidine (PCP) and related compounds. The NMDA receptor has been demonstrated to play an essential role in long-term potentiation (LTP), a phenomenon that has been implicated to be the basis for learning and memory. The influx of calcium as a result of channel activation is thought to be responsible for neuronal plasticity and glutamate neurotoxicity. A number of different NMDA receptor subunits have been cloned that may possess different functional and localization properties. The NMDA-R1 subunit (NR1) is expressed throughout the brain, while the NMDA-R2 subunits (NR2A, NR2B, NR2C, and NR2D) have a more specific localization pattern. The NMDA receptor subunits differ also in glycine sensitivity, the relative strength of the magnesium channel block, and their respective agonist-dependent deactivation time.

Alternate Names

glutamate [NMDA] receptor subunit zeta-1, glutamate receptor, ionotropic, N-methyl D-aspartate 1, NMDA1, NMDAR1glutamate [NMDA] receptor subunit zeta 1, NMD-R1, N-methyl-D-aspartate receptor channel, subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NR1

Gene Symbol

GRIN1

Additional NMDAR1 Products

Product Documents for NMDAR1 Antibody (JM11-26)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for NMDAR1 Antibody (JM11-26)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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