NMDAR2C Antibody - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB300-107

Novus Biologicals, part of Bio-Techne
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NB300-107
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse, Rat

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Frozen, Simple Western, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all GRIN2C/NMDAR2C Antibodies »

Product Specifications

Immunogen

Fusion protein from the N-terminal region of the NMDAR2C subunit. Accession # Q00961

Localization

Cerebellum

Specificity

Specific for endogenous levels of the ~140 kDa NR2C subunit of the NMDA receptor. Also labels the ~180 kDa NR2A and the ~180 kDa NR2B subunits of the NMDA receptor. Immunolabeling is blocked by preadsorption of antibody with the immunogen that was used to generate the antibody.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

140 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage).

Scientific Data Images for NMDAR2C Antibody - Azide and BSA Free

Western Blot: NMDAR2C AntibodyAzide and BSA Free [NB300-107]

Western Blot: NMDAR2C AntibodyAzide and BSA Free [NB300-107]

Western Blot: NMDA R, NR2C Subunit Antibody [NB300-107]

Applications for NMDAR2C Antibody - Azide and BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:1000

Immunoprecipitation

3 ul per 200 ug lysate

Western Blot

1:1000
Application Notes
This antibody cross reacts with both NR2A and NR2B, as such, results in immunohistochemistry are varied.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute with 50 uL PBS to desired concentration.

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GRIN2C/NMDAR2C

The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.

Long Name

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate, Subunit 2C

Alternate Names

NMDA R, NR2C Subunit, NMDAR2C, NR2C

Entrez Gene IDs

2905 (Human); 14813 (Mouse); 24411 (Rat)

Gene Symbol

GRIN2C

UniProt

Q00961 (Rat)

Additional GRIN2C/NMDAR2C Products

Product Documents for NMDAR2C Antibody - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for NMDAR2C Antibody - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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