NMDAR2C [p Ser1244] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-29536

Novus Biologicals, part of Bio-Techne
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NBP2-29536
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Predicted:

Bovine (100%), Canine (100%), Human (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GRIN2C/NMDAR2C Antibodies »

Product Summary for NMDAR2C [p Ser1244] Antibody

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1244 conjugated to KLH. Accession # Q00961

Modification

p Ser1244

Specificity

Specific for endogenous levels of the ~140 kDa NR2C subunit of the NMDA receptor phosphorylated at Ser1244. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

140 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for NMDAR2C [p Ser1244] Antibody

Western Blot: NMDAR2C [p Ser1244] Antibody [NBP2-29536]

Western Blot: NMDAR2C [p Ser1244] Antibody [NBP2-29536]

Western Blot: NMDAR2C [p Ser1244] Antibody [NBP2-29536] - Western blot of rat cerebellum lysate showing specific immunolabeling of the ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1244. The phosphospecificity is shown in the second lane where immunoreactivity is blocked by preadsorption with the phospho-peptide (Peptide) used as antigen but not by the dephosphopeptide (not shown).

Applications for NMDAR2C [p Ser1244] Antibody

Application
Recommended Usage

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GRIN2C/NMDAR2C

The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Phosphorylation of Ser1244 has been shown to regulate NMDA receptor channel function (Chen et al., 2006).

Long Name

Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate, Subunit 2C

Alternate Names

NMDA R, NR2C Subunit, NMDAR2C, NR2C

Entrez Gene IDs

24411 (Rat)

Gene Symbol

GRIN2C

UniProt

Q00961 (Rat)

Additional GRIN2C/NMDAR2C Products

Product Documents for NMDAR2C [p Ser1244] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for NMDAR2C [p Ser1244] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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