NPAS3 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76785

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all NPAS3 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 28 amino acid synthetic peptide from near the amino terminus of human NPAS3. The immunogen is located within amino acids 40 - 90 of NPAS3. Amino Acid Squence: QALRKEKSRDAARSRRGKENFEFYELAK

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Bovine (84%), Chicken (80%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NPAS3 Antibody - BSA Free

Western Blot: NPAS3 AntibodyBSA Free [NBP1-76785]

Western Blot: NPAS3 AntibodyBSA Free [NBP1-76785]

Western Blot: NPAS3 Antibody [NBP1-76785] - SK-N-SH cell lysate with NPAS3 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: NPAS3 Antibody - BSA Free [NBP1-76785]

Immunocytochemistry/ Immunofluorescence: NPAS3 Antibody - BSA Free [NBP1-76785]

Immunocytochemistry/Immunofluorescence: NPAS3 Antibody [NBP1-76785] - Immunofluorescence of NPAS3 in human brain tissue with NPAS3 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: NPAS3 Antibody - BSA Free [NBP1-76785]

Immunohistochemistry-Paraffin: NPAS3 Antibody - BSA Free [NBP1-76785]

Immunohistochemistry-Paraffin: NPAS3 Antibody [NBP1-76785] - Human brain tissue with NPAS3 antibody at 5 ug/ml.

Applications for NPAS3 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NPAS3

Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.

Alternate Names

Basic-helix-loop-helix-PAS protein MOP6, BHLHE12, bHLHe12FLJ11605, Class E basic helix-loop-helix protein 12, Member of PAS protein 6, MOP6FLJ10003, neuronal PAS domain protein 3, neuronal PAS domain-containing protein 3, Neuronal PAS3, PAS domain-containing protein 6, PASD6FLJ11138

Gene Symbol

NPAS3

UniProt

Q8IXF0 (Human)

Additional NPAS3 Products

Product Documents for NPAS3 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NPAS3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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