NPM1 Antibody (NPM1/3285) [DyLight 488]

DyLight 488 (Excitation = 493 nm, Emission = 518 nm)

Monoclonal Mouse IgG2c Kappa Clone # NPM1/3285

Please see the vial label for concentration. If unlisted please contact technical services.

Recombinant human NPM1 protein fragment (aa185-287) (exact sequence is proprietary) (Uniprot: P06748)

Nuclear and Cytoplasmic

Recognizes a 33kDa glycoprotein, identified as NPM1 (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia.

Acute Myeloid Leukemia Marker

Monoclonal

Mouse

IgG2c Kappa

Protein A or G purified

50mM Sodium Borate

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.