NRIF3 Antibody (3F6)

Novus Biologicals, part of Bio-Techne | Catalog # H00023421-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 3F6

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all NRIF3 Antibodies »

Product Specifications

Immunogen

ITGB3BP (AAH14385, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELENLIGISCASHFLKREMQKTK

Reactivity Notes

Human. Other species not tested.

Specificity

ITGB3BP - integrin beta 3 binding protein (beta3-endonexin)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for NRIF3 Antibody (3F6)

Western Blot: NRIF3 Antibody (3F6) [H00023421-M01]

Western Blot: NRIF3 Antibody (3F6) [H00023421-M01]

Western Blot: NRIF3 Antibody (3F6) [H00023421-M01] - ITGB3BP monoclonal antibody (M01), clone 3F6 Analysis of ITGB3BP expression in A-431.
Immunocytochemistry/ Immunofluorescence: NRIF3 Antibody (3F6) [H00023421-M01]

Immunocytochemistry/ Immunofluorescence: NRIF3 Antibody (3F6) [H00023421-M01]

Immunocytochemistry/Immunofluorescence: NRIF3 Antibody (3F6) [H00023421-M01] - Analysis of monoclonal antibody to ITGB3BP on A-431 cell. Antibody concentration 10 ug/ml.
Western Blot: NRIF3 Antibody (3F6) [H00023421-M01]

Western Blot: NRIF3 Antibody (3F6) [H00023421-M01]

Western Blot: NRIF3 Antibody (3F6) [H00023421-M01] - Analysis of ITGB3BP expression in transfected 293T cell line by ITGB3BP monoclonal antibody (M01), clone 3F6.Lane 1: ITGB3BP transfected lysate(20.2 KDa).Lane 2: Non-transfected lysate.
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Applications for NRIF3 Antibody (3F6)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against cell lysate and recombinant protein for Western Blot. Has also been used for immunofluoresence and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: NRIF3

Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex

Alternate Names

beta-3-endonexin, CENP-R, centromere protein R, HSU37139, integrin beta 3 binding protein (beta3-endonexin), Integrin beta-3-binding protein, NRIF3CENPRbeta 3 endonexin, Nuclear receptor-interacting factor 3, TAP20

Entrez Gene IDs

23421 (Human)

Gene Symbol

ITGB3BP

OMIM

605494 (Human)

UniProt

AAH14385 (Human)

Additional NRIF3 Products

Product Documents for NRIF3 Antibody (3F6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for NRIF3 Antibody (3F6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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