Nurr1/NGFI-B beta/NR4A2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87765

Novus Biologicals, part of Bio-Techne
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NBP1-87765
NBP1-87765-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Nurr1/NGFI-B beta/NR4A2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKP

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Nurr1/NGFI-B beta/NR4A2 Antibody

Immunocytochemistry/ Immunofluorescence: Nurr1/NGFI-B beta/NR4A2 Antibody [NBP1-87765]

Immunocytochemistry/ Immunofluorescence: Nurr1/NGFI-B beta/NR4A2 Antibody [NBP1-87765]

Immunocytochemistry/Immunofluorescence: Nurr1/NGFI-B beta/NR4A2 Antibody [NBP1-87765] - Staining of human cell line SiHa shows localization to nuclear speckles. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Nurr1/NGFI-B beta/NR4A2 Antibody [NBP1-87765]

Immunohistochemistry-Paraffin: Nurr1/NGFI-B beta/NR4A2 Antibody [NBP1-87765]

Immunohistochemistry-Paraffin: Nurr1/NGFI-B beta/NR4A2 Antibody [NBP1-87765] - Staining of human kidney shows moderate membranous and nuclear positivity in cells in tubules.

Applications for Nurr1/NGFI-B beta/NR4A2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Nurr1/NGFI-B beta/NR4A2

The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's. Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype. In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.

Long Name

Nur-related Factor 1/Nerve Growth Factor Induced B beta/Nuclear Receptor Subfamily 4, Group A, 2

Alternate Names

NGFI-B beta, NOT, NR4A2, TINUR

Gene Symbol

NR4A2

Additional Nurr1/NGFI-B beta/NR4A2 Products

Product Documents for Nurr1/NGFI-B beta/NR4A2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Nurr1/NGFI-B beta/NR4A2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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