Otoferlin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85233

Novus Biologicals, part of Bio-Techne
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NBP1-85233
NBP1-85233-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (97%), Rat (98%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Otoferlin Antibodies »

Product Summary for Otoferlin Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: PIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Otoferlin Antibody

Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233]

Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233]

Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233] - Staining of human liver shows no positivity in hepatocytes as expected.
Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233]

Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233]

Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233] - Staining of human caudate shows strong positivity in processes.
Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233]

Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233]

Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-85233] - Staining of human caudate nucleus shows moderate membranous positivity in neuropil.
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Applications for Otoferlin Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
IHC-P, HIER pH6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Otoferlin

Otoferlin might be involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Mutations in the gene for Otoferlin are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has 3 C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has 6 C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multiple isoforms have been found for this gene.

Alternate Names

AUNB1, DFNB6, DFNB9, EC 2.7.10.1, EC 4.2.1.11, FER1L2NSRD9, Fer-1-like protein 2, otoferlin

Entrez Gene IDs

9381 (Human)

Gene Symbol

OTOF

UniProt

Q9HC10 (Human)

Additional Otoferlin Products

Product Documents for Otoferlin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Otoferlin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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