The alpha, beta, delta, and gamma -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. alpha-catenin, a 102 kDa protein, interacts with E-cadherin associated protein, and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. The 92 kDa beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin also complexes with the tumor suppressor protein APC. delta-catenin interacts with Presenilin 1 and is expressed in the brain. The gene encoding delta-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding delta-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. gamma-catenin, also known as plakoglobin, is an 80-88 kDa protein that binds alpha-catenin and N-cadherin. In addition, the transmembrane phosphatase PTPm associates with catenin/cadherin complexes and may regulate complex signaling.

Alternate Names

Cadherin-associated Src substrate, CAS, catenin (cadherin-associated protein), delta 1, catenin delta-1, CTNND, KIAA0384P120CAS, p120, p120 catenin, p120(CAS), p120(CTN), p120cas, p120ctn

Gene Symbol

CTNND1

Additional p120-catenin Products

Product Documents for p120-catenin Antibody (25a) [Janelia Fluor® 646]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for p120-catenin Antibody (25a) [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

Spectra Viewer
Flow Cytometry

p120-catenin Antibody (25a) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-54411JF646

Key Product Details

Species Reactivity

Validated:

Applications

Label

Antibody Source

Concentration

View all p120-catenin Antibodies »

Product Summary for p120-catenin Antibody (25a) [Janelia Fluor® 646]

Immunogen

Localization

Clonality

Host

Isotype

Applications for p120-catenin Antibody (25a) [Janelia Fluor® 646]

CyTOF-ready

ELISA

Flow Cytometry

Immunocytochemistry/ Immunofluorescence

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: p120-catenin

Alternate Names

Gene Symbol

Additional p120-catenin Products

Product Documents for p120-catenin Antibody (25a) [Janelia Fluor® 646]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for p120-catenin Antibody (25a) [Janelia Fluor® 646]

CONTACT INFORMATION

Stay Connected