p23/PTGES3 Antibody (3H1-2A8)

Novus Biologicals, part of Bio-Techne | Catalog # H00010728-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 3H1-2A8

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all p23/PTGES3 Antibodies »

Product Specifications

Immunogen

TEBP (AAH03005, 1 a.a. ~ 160 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE

Reactivity Notes

Human. Other species not tested.

Localization

Cytoplasmic

Specificity

PTGES3 - unactive progesterone receptor, 23 kD

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for p23/PTGES3 Antibody (3H1-2A8)

Western Blot: p23/PTGES3 Antibody (3H1-2A8) [H00010728-M01]

Western Blot: p23/PTGES3 Antibody (3H1-2A8) [H00010728-M01]

Western Blot: p23/PTGES3 Antibody (3H1-2A8) [H00010728-M01] - TEBP monoclonal antibody (M01), clone 3H1-2A8 Analysis of TEBP expression in HeLa.
Immunohistochemistry-Paraffin: p23/PTGES3 Antibody (3H1-2A8) [H00010728-M01]

Immunohistochemistry-Paraffin: p23/PTGES3 Antibody (3H1-2A8) [H00010728-M01]

Immunohistochemistry-Paraffin: p23/PTGES3 Antibody (3H1-2A8) [H00010728-M01] - Analysis of monoclonal antibody to PTGES3 on formalin-fixed paraffin-embedded human liver. Antibody concentration 3 ug/ml.
Sandwich ELISA: p23/PTGES3 Antibody (3H1-2A8) [H00010728-M01] - Detection limit for recombinant GST tagged PTGES3 is approximately 3ng/ml as a capture antibody.

Applications for p23/PTGES3 Antibody (3H1-2A8)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: p23/PTGES3

p23 is a 23kDa ubiquitous, highly conserved co-chaperone for Hsp90. p23 binds Hsp90 and participates in the folding of a number of cell regulatory proteins. p23 is thought to modulate Hsp90 activity in the last stages of the chaperoning pathway and only binds Hsp90 that is in turn bound to ATP which stablizes this state of Hsp90. p23 is a prominent target in leukemic cell apoptosis and may be an important target for antileukemic treatment. Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP 70 and HSP 90), immunosuppressant binding proteins called immunophilins (the FK 506 binding proteins, FKBP 52 & FKBP 54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP 70, HSP 90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP 90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.

Long Name

Prostaglandin E Synthase 3 (Cytosolic)

Alternate Names

CPGES, PTGES3, TEBP

Entrez Gene IDs

10728 (Human)

Gene Symbol

PTGES3

OMIM

607061 (Human)

UniProt

AAH03005 (Human)

Additional p23/PTGES3 Products

Product Documents for p23/PTGES3 Antibody (3H1-2A8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for p23/PTGES3 Antibody (3H1-2A8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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