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P2Y12/P2RY12 Antibody (PSH04-48)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-32622

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-32622

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # PSH04-48

Concentration

1 mg/ml

Product Specifications

Immunogen

Synthetic peptide. (Uniprot: Q9H244)

Localization

Cell membrane.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

39 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for P2Y12/P2RY12 Antibody (PSH04-48)

P2Y12/P2RY12 Antibody (PSH04-48)

Immunohistochemistry-Frozen: P2Y12/P2RY12 Antibody (PSH04-48) [NBP3-32622]

Immunohistochemistry-Frozen: P2Y12/P2RY12 Antibody (PSH04-48) [NBP3-32622] - Immunofluorescence analysis of frozen mouse brain tissue with Rabbit anti-P2Y12/P2RY12 antibody (NBP3-32622) at 1/200 dilution.

The section was not undergone antigen retrieval. The tissues were blocked in 10% negative goat serum for 1 hour at room temperature, washed with PBS, and then probed with the primary antibody (NBP3-32622, green) at 1/200 dilution overnight at 4℃, washed with PBS. Goat Anti-Rabbit IgG H&L (iFluor™ 488) was used as the secondary antibody at 1/1,000 dilution. Nuclei were counterstained with DAPI (blue).
P2Y12/P2RY12 Antibody (PSH04-48)

Immunohistochemistry: P2Y12/P2RY12 Antibody (PSH04-48) [NBP3-32622]

Immunohistochemistry: P2Y12/P2RY12 Antibody (PSH04-48) [NBP3-32622] - Immunohistochemical analysis of paraffin-embedded human brain tissue with Rabbit anti-P2Y12/P2RY12 antibody (NBP3-32622) at 1/1,000 dilution.

The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (NBP3-32622) at 1/1,000 dilution for 1 hour at room temperature. The detection was performed using an HRP conjugated compact polymer system. DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Applications for P2Y12/P2RY12 Antibody (PSH04-48)

Application
Recommended Usage

Immunohistochemistry-Frozen

1:200

Immunohistochemistry-Paraffin

1:1000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH7.4), 0.1% BSA and 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: P2Y12/P2RY12

P2Y12 is a Purinergic Receptor essential for the aggregation of blood platelets. There is evidence that mutations in P2Y12 cause a bleeding disorder, suggesting that knowledge of the P2Y12 receptor could advance the development of antiplatelet agents to treat cardiovascular diseases. Expression of P2Y12 has been reported in platelets, spinal cord, and many brain regions. ESTs for P2Y12 have been isolated from B-cell/lung/testis, brain, embryo, prostate, eye, kidney carcinoma, and colon carcinoma libraries. Cognate

Long Name

P2Y Purinergic Receptor 12

Alternate Names

ADPG-R, HORK3, P2RY12, SP1999

Gene Symbol

P2RY12

Additional P2Y12/P2RY12 Products

Product Documents for P2Y12/P2RY12 Antibody (PSH04-48)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for P2Y12/P2RY12 Antibody (PSH04-48)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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