Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (92%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all PAK7 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK5. The immunogen is located within amino acids 240 - 290 of PAK5. Amino Acid Squence: GPSLDDYDRRPKS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PAK7 Antibody - BSA Free

Western Blot: PAK7 AntibodyBSA Free [NBP1-77237]

Western Blot: PAK7 AntibodyBSA Free [NBP1-77237]

Western Blot: PAK7 Antibody [NBP1-77237] - T24 lysate with PAK5 antibody at (A) 2 and (B) 4 u/mL.
Immunocytochemistry/ Immunofluorescence: PAK7 Antibody - BSA Free [NBP1-77237]

Immunocytochemistry/ Immunofluorescence: PAK7 Antibody - BSA Free [NBP1-77237]

Immunocytochemistry/Immunofluorescence: PAK7 Antibody [NBP1-77237] - K562 cells with PAK5 antibody at 2 ug/mL.
PAK7 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: PAK7 Antibody - BSA Free [NBP1-77237] -

Immunocytochemistry/ Immunofluorescence: PAK7 Antibody - BSA Free [NBP1-77237] - Immunofluorescence of PAK7 in K562 cells with PAK7 antibody at 10 ug/mL.

Applications for PAK7 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

2-10 ug/ml

Western Blot

2-4 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PAK7

The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK5 was initially identified as a kinase expressed primarily in brain that while possessing a kinase domain and GTPase binding domain similar to PAK4 and PAK6, is completely different from both. Expression of PAK5 in neural based cell lines resulted in neurite outgrowth suggesting that PAK5 may be involved in regulating the cytoskeletal changes necessary for promoting neurite outgrowth. Other experiments suggest that unlike the other PAKs, PAK5 may inhibit apoptosis by phosphorylating the Bcl-2 family member Bad.

Long Name

p21/Cdc42/Rac1-activated Kinase 7

Alternate Names

PAK5

Gene Symbol

PAK5

UniProt

Q9P286

Additional PAK7 Products

Product Documents for PAK7 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PAK7 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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