Pappalysin-1/PAPP-A Antibody (H6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-41228

Novus Biologicals, part of Bio-Techne
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NBP3-41228
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # H6

Concentration

1 mg/ml

View all Pappalysin-1/PAPP-A Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Human Pappalysin-1/PAPP-A (Uniprot#: Q13219; Thr1270-Cys1558 (Uniprot#: Q13219)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for Pappalysin-1/PAPP-A Antibody (H6)

Pappalysin-1/PAPP-A Antibody (H6)

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (H6) [NBP3-41228] -

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (H6) [NBP3-41228] - DAB staining on IHC-P; Sample: Human Placenta Tissue; Primary Ab: 20ug/ml NBP3-41228; Second Ab: 2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody

Applications for Pappalysin-1/PAPP-A Antibody (H6)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

5-20ug/mL

Immunohistochemistry

5-20ug/mL

Western Blot

0.5-2ug/mL

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.01M PBS, pH7.4, 50% glycerol

Preservative

0.05% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Pappalysin-1/PAPP-A

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

Long Name

Pregnancy-associated Plasma Protein 1

Alternate Names

ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A1, PAPPA, Pappalysin1

Gene Symbol

PAPPA

Additional Pappalysin-1/PAPP-A Products

Product Documents for Pappalysin-1/PAPP-A Antibody (H6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Pappalysin-1/PAPP-A Antibody (H6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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