Pappalysin-1/PAPP-A Products
Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF. Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45% amino acid identity with PAPP-A and cleaves IGFBP-2.
119 results for "Pappalysin-1/PAPP-A" in Products
119 results for "Pappalysin-1/PAPP-A" in Products
Pappalysin-1/PAPP-A Products
Pappalysins comprise one of the five families of Metzincins (other families include ADAMs/ADAMTSs, MMPs, Astacins, and Serralysins). Pappalysin-1 (PAPP-A) is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy. Reduced maternal serum PAPP-A is a major marker of Down syndrome in the first trimester of pregnancy. PAPP-A cleaves IGFBP-4 and -5 (insulin-like growth factor-binding protein-4 and 5) at a single site, resulting in the release of bioactive IGF. Pappalysin-2 (PAPP-A2; also called PAPP-E) shares 45% amino acid identity with PAPP-A and cleaves IGFBP-2.
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #PAPPA/8804R |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #PAPPA/8804R |
| Applications: | IHC |
| Sensitivity: | 0.116 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.78 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma) |
| Source: | NS0 |
| Accession #: | Q13219 |
| Applications: | EnzAct |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IP |
Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
| Assay Range: | 0.781 - 50 ng/mL |
| Applications: | ELISA |
| Source: | NS0 |
| Accession #: | Q8R4K8-1 |
| Applications: | EnzAct |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #10E1cc |
| Applications: | WB, ELISA, IP |
![Western Blot: Pappalysin-1/PAPP-A Antibody (10E1cc) [NB120-8346]](https://resources.bio-techne.com/images/products/PAPP-A-Antibody-10E1-Western-Blot-NB120-8346-img0002.jpg "Western Blot: Pappalysin-1/PAPP-A Antibody (10E1cc) [NB120-8346]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087]](https://resources.bio-techne.com/images/products/Pappalysin-1-PAPP-A-Antibody-Immunohistochemistry-Paraffin-NBP1-90087-img0012.jpg "Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #9 |
| Applications: | IHC, WB, ELISA |
![Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (9) - BSA Free [NBP1-05116]](https://resources.bio-techne.com/images/products/Pappalysin-1-PAPP-A-Antibody-NA-BSA-Free-Immunohistochemistry-Paraffin-NBP1-05116-img0002.jpg "Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (9) - BSA Free [NBP1-05116]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #PAPP A1-24 |
| Applications: | IHC, WB, ELISA |
![Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (PAPP A1-24) - BSA Free [NBP1-05043]](https://resources.bio-techne.com/images/products/Pappalysin-1-PAPP-A-Antibody-PAPP-A1-24-BSA-Free-Immunohistochemistry-Paraffin-NBP1-05043-img0001.jpg "Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (PAPP A1-24) - BSA Free [NBP1-05043]")
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #7A6 |
| Applications: | ELISA, IP |
![Western Blot: Pappalysin-1/PAPP-A Antibody (7A6) [NB100-73060]](https://resources.bio-techne.com/images/products/Pappalysin-1-PAPP-A-Antibody-7A6-Western-Blot-NB100-73060-img0003.jpg "Western Blot: Pappalysin-1/PAPP-A Antibody (7A6) [NB100-73060]")
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #PAPP A 1-1 |
| Applications: | IHC, WB, ELISA |
![Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (PAPP A 1-1) - BSA Free [NBP2-21614]](https://resources.bio-techne.com/images/products/Pappalysin-1-PAPP-A-Antibody-PAPP-A-1-1-BSA-Free-Immunohistochemistry-Paraffin-NBP2-21614-img0001.jpg "Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody (PAPP A 1-1) - BSA Free [NBP2-21614]")
| Applications: | AC |
| Reactivity: | Human, Rat |
| Details: | Mouse IgG1 kappa Monoclonal Clone #C5 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #H6 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #H4 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #5H9 |
| Applications: | ELISA, IP |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #10E2cc |
| Applications: | ELISA, IP |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #9 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #PAPP A1-24 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #PAPP A 1-1 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #10E1cc |
| Applications: | WB, ELISA, IP |