Pappalysin-1/PAPP-A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90087

Novus Biologicals, part of Bio-Techne
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NBP1-90087
NBP1-90087-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (92%), Rat (92%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Pappalysin-1/PAPP-A Antibodies »

Product Summary for Pappalysin-1/PAPP-A Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRKDL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Pappalysin-1/PAPP-A Antibody

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087]

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087]

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087] - Staining in human placenta and skeletal muscle tissues . Corresponding PAPPA RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087]

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087]

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087] - Staining of human skeletal muscle shows no cytoplasmic positivity in myocytes as expected.
Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087]

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087]

Immunohistochemistry-Paraffin: Pappalysin-1/PAPP-A Antibody [NBP1-90087] - Staining of human endometrium shows moderate to strong cytoplasmic positivity in glandular cells.
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Applications for Pappalysin-1/PAPP-A Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Pappalysin-1/PAPP-A

PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).

Long Name

Pregnancy-associated Plasma Protein 1

Alternate Names

ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A1, PAPPA, Pappalysin1

Gene Symbol

PAPPA

Additional Pappalysin-1/PAPP-A Products

Product Documents for Pappalysin-1/PAPP-A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Pappalysin-1/PAPP-A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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