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Parkin Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-41287

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Fish - Danio rerio (Zebrafish)

Applications

Validated:

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid peptide near the amino terminus of human PARK2. The immunogen is located within amino acids 110 - 160 of PARK2. Amino Acid Squence: HTDSRKDSPPAGSPAG

Specificity

PARK2 antibody is human specific.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Parkin Antibody - BSA Free

Western Blot: Parkin AntibodyBSA Free [NBP2-41287]

Western Blot: Parkin AntibodyBSA Free [NBP2-41287]

Western Blot: Parkin Antibody [NBP2-41287] - Analysis of PARK2 in human cerebellum tissue lysate with PARK2 antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: Parkin Antibody - BSA Free [NBP2-41287]

Immunohistochemistry-Paraffin: Parkin Antibody - BSA Free [NBP2-41287]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-41287] - Human brain tissue with PARK2 antibody at 5 ug/ml.

Immunohistochemistry: Parkin Antibody [NBP2-41287] -

Immunohistochemistry: Parkin Antibody [NBP2-41287] - Human brain tissue with PARK2 antibody at 20 ug/ml.

Applications for Parkin Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Parkin

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.

Long Name

Parkinson Disease [autosomal recessive, juvenile] 2, Parkin [PARK2], transcript variant 1

Alternate Names

AR-JP, PARK2, PDJ, PRKN

Gene Symbol

PRKN

Additional Parkin Products

Product Documents for Parkin Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Parkin Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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