Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # PGF 44C

Format

BSA Free

Concentration

1 mg/ml

View all PD-ECGF/Thymidine Phosphorylase Antibodies »

Product Specifications

Immunogen

Full length human protein in E. coli

Localization

Cytoplasmic and nuclear.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free

Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free [NB100-2737]

Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free [NB100-2737]

Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) [NB100-2737] - Immunohistochemical staining of thymidine phosphorylase (TP) expression and related markers in benign lymph node. In benign lymph node, TP expression highlights the meshwork of macrophages (arrow in inset; 400x) and endothelial cells (arrowhead in inset; 400x). Images are from an Olympus BX41 microscope (Olympus Corp., Tokyo, Japan) processed with Qcapture Pro 5.1 (QImaging, Surrey, BC, Canada). Image collected and cropped by CiteAb from the following publication (https://www.hindawi.com/journals/ah/2011/875135/) licensed under a CC-BY license.
Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free [NB100-2737]

Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free [NB100-2737]

Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) [NB100-2737] - Immunohistochemical staining of thymidine phosphorylase (TP) expression and related markers in benign lymph node in lymph node with malignant mycosis fungoides/Sezary syndrome cells (LN-MF). CD21 is negative in this case of LN-MF. Images are from an Olympus BX41 microscope (Olympus Corp., Tokyo, Japan) processed with Qcapture Pro 5.1 (QImaging, Surrey, BC, Canada). Image collected and cropped by CiteAb from the following publication (https://www.hindawi.com/journals/ah/2011/875135/) licensed under a CC-BY license.
Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free [NB100-2737]

Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free [NB100-2737]

Immunohistochemistry: PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) [NB100-2737] - Immunohistochemical staining of thymidine phosphorylase (TP) expression and related markers in benign lymph node in lymph node with malignant mycosis fungoides/Sezary syndrome cells (LN-MF). LN-MF: hematoxylin and eosin (H&E) stain. Images are from an Olympus BX41 microscope (Olympus Corp., Tokyo, Japan) processed with Qcapture Pro 5.1 (QImaging, Surrey, BC, Canada). Image collected and cropped by CiteAb from the following publication (https://www.hindawi.com/journals/ah/2011/875135/) licensed under a CC-BY license.
View 4 more images

Applications for PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10 - 1:500

Immunohistochemistry

1:10 - 1:500

Immunoprecipitation

1:10 - 1:500

Western Blot

1:100-1:2000
Application Notes
PGF 44C blocks enzyme activity. Positive control(s): HUVEC cell or breast carcinoma.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: PD-ECGF/Thymidine Phosphorylase

Platelet - derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

Long Name

Platelet-derived Endothelial Cell Growth Factor

Alternate Names

dThdPase, ECGF1, Gliostatin, MEDPS1, MNGIE, MTDPS1, PDECGF, TdRPase, Thymidine Phosphorylase, TPase, TYMP

Entrez Gene IDs

1890 (Human); 72962 (Mouse); 315219 (Rat)

Gene Symbol

TYMP

Additional PD-ECGF/Thymidine Phosphorylase Products

Product Documents for PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PD-ECGF/Thymidine Phosphorylase Antibody (PGF 44C) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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